8:00 am Check-In & Light Breakfast
8:50 am Chair’s Opening Remarks
Maximizing the Longevity & Potency of Circular & Self-Amplifying RNA Therapies for Optimal Treatment of a Wide Range of Diseases
9:00 am Deep-Dive Workshop: Understanding Circular & Self-Amplifying RNAs Unique Potential as More Durable & Stable Therapeutics for Treating Patients in Need
Synopsis
Circular RNA and self-amplifying RNA have many differences to linear mRNA, they have greater stability and durability, however, it’s vital to understand how these properties can be taken advantage of for developing efficacious and safe therapeutics to treat a wide array of diseases which are currently undruggable.
This session will deep dive into:
- Evaluating the advantages and disadvantages of circular RNA and self-amplifying RNA payloads over traditional linear mRNA
- Uncovering the optimal applications of next generation RNA therapeutics
- What cross-learnings can be taken from the linear mRNA field to advance new and innovative RNA therapeutics
New Data
New Company
10:15 am Morning Break & Speed Networking
Synopsis
This session is your opportunity to get face-to-face with many of the brightest minds working in the circular and self-amplifying RNA field, and establish meaningful business relationships to pursue for the rest of the conference
Leveraging AI & Analytical Methods to Improve RNA Design & Quality for More Potent Next Generation RNA Therapeutics
11:15 am Advancing Analytical Methods Enabling Circular RNA Pharmaceutical Preparedness
Synopsis
• Discuss strategies to develop new methods for circular RNA while leveraging platformed methods from linear mRNA where possible
• Review orthogonal analytical approaches for confirming identity of circular RNA and associated impurities
• Uncovering analytical methods for supporting quality control processes for circular RNA payloads
New Data
New Company
11:45 am Roundtable Discussion: Harnessing AI & Computational Modelling for Designing Circular & Self-Amplifying RNA Constructs with Improved Efficacy & Reduced Immunogenicity
Synopsis
• Navigating the potential of incorporating computational techniques in the discovery and development of RNA therapeutics
• Highlighting the use of AI and computational modelling into sequence design and immune response prediction for more efficacious therapeutics
• How to use AI to design RNA constructs which will translate well in vivo and create long lasting results?
12:30 pm Lunch & Networking
Unlocking the Priorities & Investment Opportunities for the Next Generation RNAs to Ensure Better Drugs Reach Patients Faster
1:30 pm CircVec – Deploying Circular RNA to Enhance Nucleic Acid Medicines
Synopsis
- Circio´s circVec technology is based on a genetic cassette for in situ circular RNA production
- CircVec extends mRNA half-life by 70x and protein expression level by 15-fold
- How the circVec platform can be applied to enhance DNA and viral format therapeutics for next generation gene and cell therapy
New Company
2:00 pm Fireside Chat: Unlocking Priorities for the Next Generation RNA Community to Increase Investment for Driving More Therapeutics to the Patients in Need
Synopsis
- What innovations need to come through to unleash the next frontiers in next generation RNA therapeutic development?
- Identifying future trends and opportunities within investment for circular and self-amplifying RNA therapeutics
- Highlighting priority actions for the circular and self-amplifying RNA community to drive success in 2025
2:45 pm Afternoon Networking Break & Scientific Poster Session
Synopsis
Contribute to the conversation and share your cutting-edge research with your fellow RNA community to showcase your breakthrough discoveries to a vast audience of experts. Register your place to submit an abstract for review to showcase your poster*
*Please visit the website for the T&Cs for presenting a poster
Optimizing Manufacturing & Circularization Strategies for Large-Scale Production of Pure Therapies for the Patients in Need
3:30 pm Roundtable Discussion: Navigating Manufacturing Challenges for Circular & Self-Amplifying RNA to Improve Scalability, Purity & Yield for Regulatory Approval
Synopsis
• Improving manufacturing processes for enabling large scale production of circular and self-amplifying RNA therapeutics
• Delving into best practices in manufacturing, scaling up and purification of next generation RNA therapeutics
• Discussing learnings which can be taken from the standard linear mRNA production process
4:15 pm Improving Scalability & Quality of Circular RNAs for Vaccine Development
Synopsis
• Highlighting novel methods for accurate and reliable circularization of the mRNA
• Uncovering methods for improving CMC of circular RNAs to enable large scale and high-quality production
• Showcasing advances in circular RNA for vaccines in animal medicine
New Data
New Company
4:45 pm Untangling the Impacts of Process & Manufacturing on Self-Amplifying RNA Quality & Aligning with Safety & Immunogenicity in vitro and in vivo
Synopsis
• Delving into self-amplifying RNA critical quality attributes to inform high-quality manufacturing
• Understanding impact of formulation on host response to self-amplifying RNA for more potent and efficacious therapeutics and vaccines
• Determining how self-amplifying RNA quality will impact safety and immunogenicity in vitro and in vivo
New Data
New Company