Realizing the Full Clinical Potential of Circular & Self-Amplifying RNAs Across Infectious Diseases, CAR-T Therapy, Gene Therapy & Beyond with Improved Efficacy, Functionality & Immunogenicity

May 28-29, 2025
Boston, MA

Replicate Bio - Company Logo - Circular & Self-Amplifying RNA Therapeutics
Merck - Circular & Self-Amplifying RNA Therapeutics
Sail Bio - company logo - Circular & Self-Amplifying RNA Therapeutics
Circio - company logo - Circular & Self-Amplifying RNA Therapeutics
Ribox Therapeutics - Circular & Self-Amplifying RNA Therapeutics
CSL Seqirus - company logo - Circular & saRNA Therapeutics 2025
HDT Bio company logo - Circular & Self-amplifying RNA Therapeutics 2025

Welcome to the 4th Circular & Self-Amplifying RNA Therapeutics Summit

Unleashing the Next Generation of RNAs for Widespread Therapeutic Applications

With CSL Seqirus and Arcturus Therapeutics successfully developing the first approved self-amplifying RNA vaccine, the field of next generation RNAs celebrates the potential of circular and self-amplifying RNAs to provide improved stability, durability, longevity and efficacy for treating a wide array of diseases.

This May, the 4th Circular & Self-Amplifying RNA Therapeutics Summit is landing back in Boston, as the unique opportunity to unite with leading stakeholders in the next generation RNA field, including the likes of Sail Biomedicines, Merck, Novo Nordisk, Replicate Bioscience and more. This is your one-stop shop to hear the latest approaches and applications of circular and self-amplifying RNA therapeutics and vaccines and gain actionable insights for fast-tracking your RNA programs towards the clinic.

Join 80+ RNA experts navigating through challenges such as RNA design, delivery, purity and manufacturing to accelerate high-quality and scalable next generation RNA therapeutics and vaccines towards approval and the patients in need.

What's New for 2025

4th Circular Self-Amplifying RNA Therapeutics Summit 2025 - logo

Brand New Speaker Faculty & Exclusive Data 

With over 80% new speakers from key stakeholders, hear brand-new data and insights from the likes of CSL Seqirus, Merck & Co, Sail Biomedicines, RiboX Therapeutics, VLP Therapeutics and more, gain insights into promise of circular and self-amplifying RNA for providing more durable, stable and potent therapeutics and vaccines.

4th Circular Self-Amplifying RNA Therapeutics Summit 2025 - logo

Addressing Circular & Self-Amplifying RNA Bottlenecks 

As an event-dedicated to the next generation RNA community, we're excited to provide you with deep dive workshops, data-driven presentations and interactive discussion addressing challenges in manufacturing, purification, optimal application, analysis and more to help you advance RNA therapies towards approval.

4th Circular Self-Amplifying RNA Therapeutics Summit 2025 - logo

Improving Next Generation RNA Investment 

During an interactive fireside chat with MPM Capital and Orbital Therapeutics, hear what innovations are needed to spark greater investment in the circular and self-amplifying RNA field. This session will highlight priority actions and applications for driving more success in the next generation RNA field.

Speaker Faculty

Discover our 17+ expert speakers covering all things Circular & Self-Amplifying RNA

Michael Mingueneau - Black & White Head Shot
Erik Digman Wiklund Chief Executive Officer Circio
Gilles Besin - Orbital Therapeutics

Michael
Mingueneau
Head, Immunology
Sail Biomedicines

Erik Digman
Wiklund
Chief Executive Officer
Circio

Gilles Besin
Chief Scientific
Officer
Orbital
Therapeutics

Fei Liu
Associate Director,
Molecular Biology
CSL Seqirus

Nichole Lareau
Associate Principal
Scientist
Merck & Co

Amit Khandhar
Director, Formulations
HDT Bio

“Circular RNA represents an innovative modality that offers several advantages over linear RNA. I believe that attending the meeting will provide an excellent opportunity for me to share insights and learn more about this promising form of RNA”

Gilles Besin, Chief Scientific Officer

Orbital - 4th Circular & Self-Amplifying RNA Therapeutics

Other Events in the World RNA Series

“I look forward to connecting with like-minded industry and academic peers working to advance the saRNA vaccines and therapeutics into the clinic”

Amit Khandhar, Director, Formulations

HDT Bio - 4th Circular & Self-Amplifying RNA Therapeutics